Lebeau C, Vandenesch F, Greenland T, Novick R P, Etienne J
Département de Recherche en Bactériologie Médicale EA 1655, Faculté de Médecine Alexis Carrel, Lyon, France.
J Bacteriol. 1994 Sep;176(17):5534-6. doi: 10.1128/jb.176.17.5534-5536.1994.
Expression of staphylocoagulase by agr+ Staphylococcus aureus depends on the growth phase, being maximal during exponential growth and decreasing sharply postexponentially, while an agr-deleted strain continuously expresses an intermediate level of coagulase. Therefore, coagulase expression appears to be both positively and negatively modulated by an agr-dependent mechanism.
Agr+金黄色葡萄球菌的葡萄球菌凝固酶表达取决于生长阶段，在指数生长期达到最大值，指数生长后期急剧下降，而缺失agr的菌株持续表达中等水平的凝固酶。因此，凝固酶的表达似乎受到一种依赖agr的机制的正向和负向调节。
