Gray D A
Department of Zoology and Entomology , Rhodes University, Grahamstown, South Africa.
J Comp Physiol B. 1993;163(6):519-23. doi: 10.1007/BF00346937.
Plasma atrial natriuretic factor concentrations in Rhode Island red hens averaged 72.1 +/- 6.9 pg.ml-1, range 33.4-136.0 pg.ml-1. The intravenous infusion of isotonic saline containing 3% dextran for 2 h produced no significant changes in plasma osmotic or electrolyte concentrations; however, heamatocrit changes indicated vascular expansions of 14.4% after 1 h and 21.3% after 2 h and plasma atrial natriuretic factor concentrations were elevated by 190% and 257% respectively. The intravenous infusion of chicken atrial nutriuretic factor at rates of 10, 25, 50 and 100 ng.kg-1.min-1 for 20 min produced levels of plasma atrial nutriuretic factor that were directly related to the infusion rate and which, in birds undergoing a steady-state diuresis/natriuresis driven by the intravenous infusion of isotonic saline at 1 ml.min-1, produced dose-dependent increases of 19, 26, 38 and 55% in urine flow rate and of 8, 30, 49 and 77% in sodium excretion. Potassium excretion was significantly increased only at the two highest atrial natriuretic factor infusion rates. The observed correlation between plasma atrial natriuretic factor concentration and vascular volume together with the atrial natriuretic factor-induced modulation of renal salt and water elimination is consistent with the concept that in the chicken this peptide has a physiological role as a regulatory hormone in volume homeostasis.
罗德岛红母鸡血浆心钠素浓度平均为72.1±6.9 pg.ml-1，范围为33.4 - 136.0 pg.ml-1。静脉输注含3%右旋糖酐的等渗盐水2小时，血浆渗透压或电解质浓度无显著变化；然而，血细胞比容变化表明，1小时后血管扩张14.4%，2小时后血管扩张21.3%，血浆心钠素浓度分别升高190%和257%。以10、25、50和100 ng.kg-1.min-1的速率静脉输注鸡心钠素20分钟，所产生的血浆心钠素水平与输注速率直接相关，并且在以1 ml.min-1的速率静脉输注等渗盐水驱动的稳态利尿/利钠过程中的鸟类中，尿流率剂量依赖性增加19%、26%、38%和55%，钠排泄剂量依赖性增加8%、30%、49%和77%。仅在两个最高的心钠素输注速率下，钾排泄显著增加。观察到的血浆心钠素浓度与血管容量之间的相关性以及心钠素诱导的肾脏盐和水排泄调节，与这样的概念一致，即在鸡中这种肽作为一种调节激素在容量稳态中具有生理作用。
