Katon W, Lin E, von Korff M, Bush T, Walker E, Simon G, Robinson P
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle 98195.
J Affect Disord. 1994 Jun;31(2):81-90. doi: 10.1016/0165-0327(94)90111-2.
164 patients in primary care who were recognized as depressed by their physicians and started on antidepressants were interviewed at 1 and 4 months after initiation of treatment. Ten factors hypothesized to be related to persistence of depressive symptoms were entered into a multivariate analysis to determine predictors of persistence of affective symptoms. Patients with minor depression were significantly older, more likely to be married or cohabitating, more likely to have serious medical illness, and had significantly less comorbid panic disorder, recurrent depression and lower neuroticism scores compared to patients with major depression. Approximately half of the patients in this primary care sample with major depression and one-third of those with minor depression were still distressed at 4 months, although few met criteria for major depression. Severity of depression and high neuroticism scores were the best predictors of persistent depressive symptoms.
在初级保健机构中，164名被医生诊断为抑郁症并开始服用抗抑郁药的患者在治疗开始后的1个月和4个月接受了访谈。将10个假设与抑郁症状持续存在相关的因素纳入多变量分析，以确定情感症状持续存在的预测因素。与重度抑郁症患者相比，轻度抑郁症患者年龄显著更大，更有可能已婚或同居，更有可能患有严重的内科疾病，且合并惊恐障碍、复发性抑郁症的情况显著更少，神经质得分更低。在这个初级保健样本中，约一半的重度抑郁症患者和三分之一的轻度抑郁症患者在4个月时仍感到痛苦，尽管很少有人符合重度抑郁症的标准。抑郁严重程度和高神经质得分是持续性抑郁症状的最佳预测因素。
