营养不良中的血清补体和免疫胶固素
Serum complement and immunoconglutinin in malnutrition.
作者信息
Chandra R K
出版信息
Arch Dis Child. 1975 Mar;50(3):225-9. doi: 10.1136/adc.50.3.225.
Abstract
Serum haemolytic complement activity and C3 were significantly decreased in 35 malnourished children. The changes were more pronounced in those with infection. Electrophoretically altered forms of complement C were detected in 14. There was an inverse correlation between C3 levels and immunoconglutinin titres. Nutritional rehabilitation and eradication of infection reversed the abnormalities. It is suggested that reduced complement function in malnutrition is the combined result of impaired synthesis, complement activation in vivo, and changes in plasma volume, and that it may contribute to an increased susceptibility to infection in undernourished individuals.
摘要
35名营养不良儿童的血清溶血补体活性和C3水平显著降低。在伴有感染的儿童中，这些变化更为明显。在14名儿童中检测到补体C的电泳形式改变。C3水平与免疫黏集素滴度呈负相关。营养康复和感染根除可逆转这些异常情况。提示营养不良时补体功能降低是合成受损、体内补体激活以及血容量变化共同作用的结果，并且这可能导致营养不良个体对感染的易感性增加。
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本文引用的文献
1
BLOOD AND EXTRACELLULAR FLUID STUDIES IN CHRONIC MALNUTRITION IN INFANCY.婴儿期慢性营养不良的血液及细胞外液研究
J Clin Invest. 1948 May;27(3 Pt 1):352-63. doi: 10.1172/JCI101966.
2
[Studies on the undernourished child. VII. Blood and plasma volumes in the undernourished pre-school child].[关于营养不良儿童的研究。VII. 学龄前营养不良儿童的血容量和血浆容量]
Bol Med Hosp Infant Mex. 1950 Aug;7(4):514-20.
3
PERSPECTIVES IN PROTEIN MALNUTRITION.蛋白质营养不良的研究视角
Nature. 1964 Feb 8;201:546-51. doi: 10.1038/201546a0.
4
Rheumatoid factor, complement, and conglutinin aberrations in patients with subacute bacterial endocarditis.亚急性细菌性心内膜炎患者的类风湿因子、补体及胶固素异常
J Clin Invest. 1962 Mar;41(3):666-75. doi: 10.1172/JCI104523.
5
The conglutination phenomenon. XI. Immunoconglutinin in human sera.胶凝现象。十一、人血清中的免疫胶凝素。
J Hyg (Lond). 1957 Mar;55(1):81-90. doi: 10.1017/s0022172400061271.
6
The short-term prognosis of severe primary infantile malnutrition.重度原发性婴幼儿营养不良的短期预后
Br J Nutr. 1967;21(1):155-65. doi: 10.1079/bjn19670016.
7
8
Acute glomerulonephritis associated with ECHO virus type 9 infection.与9型艾柯病毒感染相关的急性肾小球肾炎
J Pediatr. 1966 Oct;69(4):603-9. doi: 10.1016/s0022-3476(66)80047-1.
9
Serum siderophilin in kwashiorkor.夸希奥科病中的血清转铁蛋白。
Arch Dis Child. 1968 Aug;43(230):459-62. doi: 10.1136/adc.43.230.459.
10
Nitroblue tetrazolium dye test as an aid in the differential diagnosis of febrile disorders.硝基蓝四唑氮染料试验辅助发热性疾病的鉴别诊断
J Pediatr. 1971 Feb;78(2):230-7. doi: 10.1016/s0022-3476(71)80005-7.
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