营养不良中的血清补体和免疫胶固素
Serum complement and immunoconglutinin in malnutrition.
作者信息
Chandra R K
出版信息
Arch Dis Child. 1975 Mar;50(3):225-9. doi: 10.1136/adc.50.3.225.
Abstract
Serum haemolytic complement activity and C3 were significantly decreased in 35 malnourished children. The changes were more pronounced in those with infection. Electrophoretically altered forms of complement C were detected in 14. There was an inverse correlation between C3 levels and immunoconglutinin titres. Nutritional rehabilitation and eradication of infection reversed the abnormalities. It is suggested that reduced complement function in malnutrition is the combined result of impaired synthesis, complement activation in vivo, and changes in plasma volume, and that it may contribute to an increased susceptibility to infection in undernourished individuals.
摘要
35名营养不良儿童的血清溶血补体活性和C3水平显著降低。在伴有感染的儿童中，这些变化更为明显。在14名儿童中检测到补体C的电泳形式改变。C3水平与免疫黏集素滴度呈负相关。营养康复和感染根除可逆转这些异常情况。提示营养不良时补体功能降低是合成受损、体内补体激活以及血容量变化共同作用的结果，并且这可能导致营养不良个体对感染的易感性增加。
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