营养不良儿童对麻疹减毒活疫苗和脊髓灰质炎病毒疫苗的分泌性抗体反应降低。
Reduced secretory antibody response to live attenuated measles and poliovirus vaccines in malnourished children.
作者信息
Chandra R K
出版信息
Br Med J. 1975 Jun 14;2(5971):583-5. doi: 10.1136/bmj.2.5971.583.
Abstract
Serum and nasopharyngeal IgA antibody levels were estimated in 20 malnourished children and 20 matched healthy controls after immunization with a single dose of live attenuated measles or poliovirus vaccine. Seroconversion and serum neutralizing antibody titres were comparable in the two groups. Secretory IgA antibody was detected significantly less often in undernourished children; the time of its first appearance was delayed-and its maximum level was significantly lower. Impaired secretory antibody response in malnourished children may contribute to slow inadequate recovery from viral and enterobacterial infections and predispose to lifethreatening complications.
摘要
在20名营养不良儿童和20名匹配的健康对照儿童中，给予单剂量减毒活麻疹或脊髓灰质炎疫苗免疫后，测定血清和鼻咽部IgA抗体水平。两组的血清转化和血清中和抗体滴度相当。营养不良儿童中分泌型IgA抗体的检测频率明显较低；其首次出现的时间延迟，且最高水平显著降低。营养不良儿童分泌性抗体反应受损可能导致从病毒和肠道细菌感染中恢复缓慢且不完全，并易引发危及生命的并发症。
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本文引用的文献
1
Serum siderophilin in kwashiorkor.夸希奥科病中的血清转铁蛋白。
Arch Dis Child. 1968 Aug;43(230):459-62. doi: 10.1136/adc.43.230.459.
2
Impaired cellular immunity in kwashiorkor with improvement after therapy.夸希奥科病患者存在细胞免疫受损，治疗后有所改善。
Br Med J. 1971 Nov 27;4(5786):527-9. doi: 10.1136/bmj.4.5786.527.
3
Opsonic activity, phagocytosis, and bactericidal capacity of polymorphs in undernutrition.营养不良时多形核白细胞的调理活性、吞噬作用及杀菌能力
Arch Dis Child. 1972 Apr;47(252):282-4. doi: 10.1136/adc.47.252.282.
4
Immunocompetence in undernutrition.营养不良中的免疫能力。
J Pediatr. 1972 Dec;81(6):1194-200. doi: 10.1016/s0022-3476(72)80262-2.
5
Effect of acute and chronic starvation on plaque forming cell response in mice.急性和慢性饥饿对小鼠斑块形成细胞反应的影响。
Indian J Med Res. 1973 Jan;61(1):93-7.
6
Metabolic and bactericidal activities of leukocytes in protein-calorie malnutrition.蛋白质 - 热量营养不良时白细胞的代谢及杀菌活性
Am J Clin Nutr. 1972 Feb;25(2):166-74. doi: 10.1093/ajcn/25.2.166.
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Lancet. 1965 Oct 9;2(7415):719-21. doi: 10.1016/s0140-6736(65)90457-5.
8
Letter: Immunocompetence in low-birth-weight infants after intrauterine malnutrition.信函：宫内营养不良后低体重儿的免疫能力
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9
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