Moretti J L, Tamgac F, Weinmann P, Caillat-Vigneron N, Belin C A, Cesaro P, Holman B L, Defer G
Service de Médecine Nucléaire, Hôpital Avicenne, Laboratoire de Radiopharmacologie CHU Bobigny, Créteil, France.
J Nucl Med. 1994 Sep;35(9):1444-9.
The brain distribution of 99mTc-ECD versus 123I-IMP was compared in patients with subacute stroke in order to compare diagnostic accuracy.
A total of 25 patients with subacute stroke underwent early and delayed SPECT imaging with 99mTc-ECD and 123I-IMP. Washout of 99mTc-ECD was calculated and a differential percentage of activity (DPA) of ischemic versus normal zones was assessed. Images were analyzed twice by five independent observers.
Technetium-99m-ECD clearance was 12.5% from the whole brain during early imaging. Ischemic parietal zones had higher clearance than normal parietal zones. Technetium-99m-ECD images showed larger differences between abnormal and normal brain activity than 123I-IMP images. Detection accuracy was slightly, but not significantly, higher for 99mTc-ECD and 123I-IMP (sensitivity: 73.8% as 66.6%; specificity: 81.7% as 81.6%). Reproducibility among observers was similar for 99mTc-ECD and early 123I-IMP.
Technetium-99m-ECD demonstrates high diagnostic accuracy during subacute stroke, similar to 123I-IMP, but with more intense, better delineation of the perfusion defects.
为比较诊断准确性，对亚急性中风患者的99mTc-ECD与123I-IMP的脑内分布进行了比较。
25例亚急性中风患者接受了99mTc-ECD和123I-IMP的早期和延迟SPECT成像。计算99mTc-ECD的洗脱率，并评估缺血区与正常区的活性差异百分比（DPA）。图像由五名独立观察者进行两次分析。
早期成像时，全脑的99mTc-ECD清除率为12.5%。缺血性顶叶区的清除率高于正常顶叶区。99mTc-ECD图像显示异常与正常脑活动之间的差异比123I-IMP图像更大。99mTc-ECD和123I-IMP的检测准确性略高，但无显著差异（敏感性：73.8%对66.6%；特异性：81.7%对81.6%）。观察者之间对99mTc-ECD和早期123I-IMP的再现性相似。
99mTc-ECD在亚急性中风期间显示出与123I-IMP相似的高诊断准确性，但灌注缺损的显示更强烈、更清晰。
