Hayashida K, Nishimura T, Imakita S, Uehara T
Department of Diagnostic Radiology, National Cardiovascular Center, Osaka, Japan.
Ann Nucl Med. 1992 Nov;6(4):229-33. doi: 10.1007/BF03164659.
In order to evaluate the lung and brain uptake of 99mTc ethyl cysteinate dimer (99mTc-ECD) and N-isopropyl-p-[123I]-iodoamphetamine (123I-IMP), alternative body scans were carried out in 15 cases of cerebrovascular disease. The biodistribution of 99mTc-ECD was 5.5 +/- 0.7%, 3.8 +/- 0.7% in the brain; 13.1 +/- 3.7%, 2.2 +/- 1.2%, in the lung at 15 min and at 4 hours, respectively, whereas that of 123I-IMP was 3.9 +/- 1.4%, 5.0 +/- 1.0% in the brain; 32.2 +/- 7.6%, 12.7 +/- 3.3%, in the lung at 15 min and at 4 hours, respectively. 99mTc-ECD accumulated in comparatively high amounts in the brain but remained low in the lung in the early image compared to 123I-IMP. However there was a high inverse correlation between brain and lung uptake of 123I-IMP (r = -0.82), but not of 99mTc-ECD (r = -0.18). We concluded that 99mTc-ECD had a better biodistribution in terms of low lung accumulation than 123I-IMP in brain SPECT.
为了评估99mTc-乙半胱氨酸二聚体（99mTc-ECD）和N-异丙基-p-[123I]-碘安非他明（123I-IMP）在肺和脑的摄取情况，对15例脑血管疾病患者进行了替代身体扫描。99mTc-ECD在15分钟和4小时时的生物分布分别为：脑摄取率为5.5±0.7%、3.8±0.7%；肺摄取率为13.1±3.7%、2.2±1.2%。而123I-IMP在15分钟和4小时时的生物分布分别为：脑摄取率为3.9±1.4%、5.0±1.0%；肺摄取率为32.2±7.6%、12.7±3.3%。与123I-IMP相比，99mTc-ECD在早期图像中脑内蓄积量相对较高，而肺内蓄积量较低。然而，123I-IMP的脑摄取与肺摄取之间存在高度负相关（r = -0.82），而99mTc-ECD则不存在（r = -0.18）。我们得出结论，在脑SPECT中，就肺内低蓄积而言，99mTc-ECD的生物分布比123I-IMP更好。
