静脉注射免疫球蛋白期间肝炎抗体的被动转移。

Passive transfer of hepatitis antibodies during intravenous administration of immune globulin.

作者信息

Karna P, Murray D L, Valduss D, Mattarella N, Dyke J W, Maier G A

机构信息

Department of Pediatrics and Human Development, Michigan State University, East Lansing.

出版信息

J Pediatr. 1994 Sep;125(3):463-5. doi: 10.1016/s0022-3476(05)83296-2.

DOI:10.1016/s0022-3476(05)83296-2

PMID:8071759

Abstract

We studied the effect of intravenous immune globulin (IVIG) infusion on the levels of hepatitis B and C antibodies in 10 premature babies. All four tested lots of a commercially purchased IVIG preparation were found to contain substantial amounts of hepatitis B core and hepatitis C antibodies. Our results show that passive transfer of hepatitis B and C virus antibodies occurred after IVIG infusion, and that the levels were dependent on the quantity of IVIG given. When assessing neonates for hepatitis, the factor of receipt of blood products, including IVIG, needs to be considered to interpret laboratory results.

摘要

我们研究了静脉注射免疫球蛋白（IVIG）输注对10名早产儿乙肝和丙肝抗体水平的影响。发现从商业渠道购买的IVIG制剂的所有四个测试批次均含有大量乙肝核心抗体和丙肝抗体。我们的结果表明，IVIG输注后发生了乙肝和丙肝病毒抗体的被动转移，且抗体水平取决于IVIG的给药量。在评估新生儿是否感染肝炎时，需要考虑包括IVIG在内的血液制品的输注因素，以便解读实验室结果。