Varghese A, Winslow R L
Army High Performance Computing Research Center, University of Minnesota, Minneapolis 55415.
J Theor Biol. 1994 Jun 21;168(4):407-20. doi: 10.1006/jtbi.1994.1121.
A model of the electrical activity in mammalian cardiac Purkinje fiber is examined to study the effects of subcellular oscillations on the transmembrane potential. Inhibition of the sodium/potassium pump causes oscillations in the internal calcium concentration and these oscillations are shown to interfere with the normal pacemaking mechanism of the Purkinje fiber. Bifurcation diagrams were constructed using numerical continuation methods. These results predict a dramatic change in the structure of periodic orbits of the cell electrical activity with pump inhibition and elevated levels of internal sodium concentration.
研究了哺乳动物心脏浦肯野纤维电活动的模型，以探讨亚细胞振荡对跨膜电位的影响。钠/钾泵的抑制会导致细胞内钙浓度振荡，并且这些振荡会干扰浦肯野纤维的正常起搏机制。使用数值延拓方法构建了分岔图。这些结果预测，随着泵抑制和细胞内钠浓度升高，细胞电活动的周期轨道结构将发生显著变化。
