Chay T R, Lee Y S
Biophys J. 1984 Apr;45(4):841-9. doi: 10.1016/S0006-3495(84)84228-9.
We examined the effects of brief current pulses on the pacemaker oscillations of the Purkinje fiber using the model of McAllister , Noble, and Tsien (1975. J. Physiol. [Lond.]. 251:1-57). This model was used to construct phase-response curves for brief electric stimuli to find "black holes," where rhythmic activity of the Purkinje fiber ceases. In our computer simulation, a brief current stimulus of the right magnitude and timing annihilated oscillations in membrane potential. The model also revealed a sequence of alternating periodic and chaotic regimes as the strength of a steady bias current is varied. We compared the results of our computer simulations with experimental work on Purkinje fibers and pointed out the importance of modeling results of this kind for understanding cardiac arrhythmias.
我们使用麦卡利斯特、诺布尔和钱（1975年，《生理学杂志》[伦敦]，251卷：1 - 57页）的模型，研究了短暂电流脉冲对浦肯野纤维起搏器振荡的影响。该模型用于构建短暂电刺激的相位响应曲线，以找到“黑洞”，即浦肯野纤维的节律性活动停止的地方。在我们的计算机模拟中，适当大小和时间的短暂电流刺激消除了膜电位的振荡。该模型还揭示了随着稳定偏置电流强度的变化，一系列交替的周期性和混沌状态。我们将计算机模拟结果与浦肯野纤维的实验工作进行了比较，并指出了这类建模结果对于理解心律失常的重要性。
