Itoh S, Katsuura G, Itoh T, Morimoto T
Department of Physiology, Kyoto Prefectural University of Medicine, Japan.
Life Sci. 1994;55(11):PL213-6. doi: 10.1016/0024-3205(94)90049-3.
Cholecystokinin tetrapeptide (CCK-4) is likely to possess opposite central action against cholecystokinin octapeptide (CCK-8). In the present study, the behavioral effects of CCK-4 and CCK-8 were compared in frontal decorticated rats. In sham-operated rats, CCK-4 produced marked excitatory responses, while CCK-8 had no stimulatory effects. In frontal decorticated rats, CCK-4 did not cause any excitatory behaviors, while CCK-8 produced markedly enhanced responses. We speculate that an appropriate balance of these CCK peptides might be involved in the maintenance of normal mental states.
胆囊收缩素四肽（CCK - 4）可能对胆囊收缩素八肽（CCK - 8）具有相反的中枢作用。在本研究中，比较了CCK - 4和CCK - 8对额叶皮质切除大鼠的行为影响。在假手术大鼠中，CCK - 4产生明显的兴奋反应，而CCK - 8没有刺激作用。在额叶皮质切除大鼠中，CCK - 4未引起任何兴奋行为，而CCK - 8产生明显增强的反应。我们推测这些CCK肽的适当平衡可能参与维持正常的精神状态。
