Katsuura G, Itoh S
Prog Clin Biol Res. 1985;192:147-50.
Cholecystokinin octapeptide (CCK-8) and vasoactive intestinal peptide (VIP) have been shown to be antagonistic in various parameters in the rat in our previous studies. In the present investigation the effects of CCK-8 and VIP on spontaneous motility and rearing activity were observed in sham-operated and neofrontal decorticated rats. The results indicate that VIP antagonizes the effects of CCK-8 on spontaneous motility and rearing, and the effects are more apparent in the decorticated rats. It was suggested that CCK-8 affects presynaptic dopaminergic systems, while VIP is likely to stimulate post-synaptic dopaminergic mechanisms.
在我们之前的研究中，已表明胆囊收缩素八肽（CCK - 8）和血管活性肠肽（VIP）在大鼠的各种参数方面具有拮抗作用。在本研究中，观察了CCK - 8和VIP对假手术大鼠和新额叶去皮质大鼠自发运动和竖毛活动的影响。结果表明，VIP拮抗CCK - 8对自发运动和竖毛的影响，且这种影响在去皮质大鼠中更为明显。研究表明，CCK - 8影响突触前多巴胺能系统，而VIP可能刺激突触后多巴胺能机制。
