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醛固酮诱导蟾蜍膀胱膜磷脂脂肪酸代谢

Aldosterone-Induced Membrane Phospholipid Fatty Acid Metabolism in the Toad Urinary Bladder.

作者信息

Goodman D B, Wong M, Rasmussen H

出版信息

Biochemistry. 1975 Jul;14(13):2803-9. doi: 10.1021/bi00684a003.

Abstract

Aldosterone action in the isolated toad urinary bladder has been studied by incubation of the tissue with several specifically labeled lipogenic precursors. Within 30 min after hormone addition phospholipid synthesis is stimulated; the metabolism of oleic acid is particularly enhanced. Additionally, during this time interval a phospholipid deacylation-reacylation cycle is stimulated by aldosterone.

摘要

通过将蟾蜍离体膀胱组织与几种特异性标记的脂肪生成前体一起孵育,对醛固酮在其中的作用进行了研究。添加激素后30分钟内,磷脂合成受到刺激;油酸的代谢尤其增强。此外,在此时间间隔内,醛固酮刺激了磷脂脱酰基-再酰基化循环。

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