van der Klauw M M, Stricker B H
Afd. Inwendige Geneeskunde, Erasmus Universiteit, Rotterdam.
Ned Tijdschr Geneeskd. 1994 Aug 6;138(32):1628-31.
Nicotine-containing patches are prescribed to facilitate tobacco withdrawal by mitigating abstinence symptoms and diminishing craving. In clinical trials local skin reactions were often recorded as a reaction to the patches. Systemic skin reactions were described, but only rarely. The Netherlands Centre for Monitoring of Adverse Reactions to Drugs received II reports of local and 5 reports of systemic skin reactions to nicotine patches during the period January 1993 until April 1994. Skin reactions usually occur after about 15 days' use and local reactions tend to become worse when treatment is continued. The mechanism of the reaction and the part of the patch to which the skin reacts are still unclear.
含尼古丁贴片被用于通过减轻戒断症状和减少渴望来促进戒烟。在临床试验中，局部皮肤反应经常被记录为对贴片的反应。全身性皮肤反应也有描述，但很罕见。荷兰药品不良反应监测中心在1993年1月至1994年4月期间收到了11份关于尼古丁贴片局部皮肤反应的报告和5份全身性皮肤反应的报告。皮肤反应通常在使用约15天后出现，并且在持续治疗时局部反应往往会加重。反应机制以及皮肤对贴片哪一部分产生反应仍不清楚。
