Van der Klauw M M, Van Hillo B, Van den Berg W H, Bolsius E P, Sutorius F F, Stricker B H
Netherlands Centre for Monitoring of Adverse Reactions to Drugs, Rijswijk.
Br J Dermatol. 1996 Feb;134(2):361-4.
Nicotine-containing patches are used to facilitate tobacco withdrawal by mitigating abstinence symptoms and diminishing craving. We describe two patients who developed vasculitis in association with the use of a nicotine patch. The first concerns a patient who developed fever, arthritis, a generalized erythema and purpuric lesions, after 3 days use of nicotine patches. Laboratory results and a skin biopsy confirmed the diagnosis of a leucocytoclastic vasculitis. After stopping use of the patch, the patient recovered. On challenge, the symptoms reappeared. The second patient developed purpuric lesions during the use of nicotine patches, and recovered fully after these were stopped. In these patients, nicotine patches seem to be causally related to the development of vasculitis.
含尼古丁贴片用于通过减轻戒断症状和减少渴望来促进戒烟。我们描述了两名使用尼古丁贴片后发生血管炎的患者。第一例涉及一名患者，在使用尼古丁贴片3天后出现发热、关节炎、全身性红斑和紫癜性病变。实验室检查结果和皮肤活检确诊为白细胞破碎性血管炎。停用贴片后，患者康复。再次使用时，症状再次出现。第二例患者在使用尼古丁贴片期间出现紫癜性病变，停用后完全康复。在这些患者中，尼古丁贴片似乎与血管炎的发生有因果关系。
