Palm D E, Keil L C, Severs W B
Department of Pharmacology, College of Medicine, Pennsylvania State University, Hershey 17033.
Proc Soc Exp Biol Med. 1994 Sep;206(4):392-5. doi: 10.3181/00379727-206-43776.
Angiotensin (Ang), vasopressin (VP) and atrial natriuretic peptide (ANP) were assayed in the anterior uvea and retina from eyes of decapitated rats and rats perfused through the heart with phosphate buffered saline to remove peptides from blood and ocular fluids. All peptides were detected, and ANP was the most abundant. Uveal content of each peptide was greater than the retina. Perfusion did not affect ANP or VP content, but Ang was eliminated. Washout may explain the lack of immunohistochemical localization in the eye for Ang, but not VP. Also, washout does not account for available immunohistochemical data describing the localization of ANP in ocular tissue.
对断头大鼠以及经心脏灌注磷酸盐缓冲盐水以清除血液和眼内液中肽类的大鼠的前葡萄膜和视网膜进行血管紧张素（Ang）、血管加压素（VP）和心房利钠肽（ANP）检测。所有肽类均被检测到，且ANP含量最为丰富。每种肽类的葡萄膜含量均高于视网膜。灌注不影响ANP或VP的含量，但Ang被清除。洗脱可能解释了眼内缺乏Ang的免疫组化定位，但不能解释VP的情况。此外，洗脱也无法解释描述ANP在眼组织中定位的现有免疫组化数据。
