具有解热、抗心律失常、降压及其他活性的N-取代4,5(3)-二苯基-3(5)-吡唑胺类化合物。
N-substituted 4,5(3)-diphenyl-3(5)-pyrazoleamines with antipyretic, antiarrhythmic, hypotensive and other activities.
作者信息
Bruno O, Ranise A, Bondavalli F, Schenone P, D'Amico M, Filippelli A, Falciani M, Rossi F
机构信息
Istituto di Scienze Farmaceutiche dell'Università, Genova, Italy.
出版信息
Farmaco. 1993 Jul;48(7):967-77.
PMID:8397679
Abstract
The synthesis of N-substituted 4,5(3)-diphenyl-3(5)-pyrazoleamines by reaction of N-substituted 3-oxo-2,3-diphenylpropane-carbothioamides with hydrazine is described. Some compounds showed remarkable antipyretic, antiarrhythmic and hypotensive activity in rats, as well as weak antiinflammatory, analgesic and in vitro platelet antiaggregating activity.
摘要
描述了通过N-取代的3-氧代-2,3-二苯基丙烷-硫代碳酰胺与肼反应合成N-取代的4,5(3)-二苯基-3(5)-吡唑胺。一些化合物在大鼠中显示出显著的解热、抗心律失常和降压活性，以及微弱的抗炎、镇痛和体外血小板抗聚集活性。
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