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具有解热、抗心律失常、降压及其他活性的N-取代4,5(3)-二苯基-3(5)-吡唑胺类化合物。

N-substituted 4,5(3)-diphenyl-3(5)-pyrazoleamines with antipyretic, antiarrhythmic, hypotensive and other activities.

作者信息

Bruno O, Ranise A, Bondavalli F, Schenone P, D'Amico M, Filippelli A, Falciani M, Rossi F

机构信息

Istituto di Scienze Farmaceutiche dell'Università, Genova, Italy.

出版信息

Farmaco. 1993 Jul;48(7):967-77.

Abstract

The synthesis of N-substituted 4,5(3)-diphenyl-3(5)-pyrazoleamines by reaction of N-substituted 3-oxo-2,3-diphenylpropane-carbothioamides with hydrazine is described. Some compounds showed remarkable antipyretic, antiarrhythmic and hypotensive activity in rats, as well as weak antiinflammatory, analgesic and in vitro platelet antiaggregating activity.

摘要

描述了通过N-取代的3-氧代-2,3-二苯基丙烷-硫代碳酰胺与肼反应合成N-取代的4,5(3)-二苯基-3(5)-吡唑胺。一些化合物在大鼠中显示出显著的解热、抗心律失常和降压活性，以及微弱的抗炎、镇痛和体外血小板抗聚集活性。

相似文献

1

N-substituted 4,5(3)-diphenyl-3(5)-pyrazoleamines with antipyretic, antiarrhythmic, hypotensive and other activities.具有解热、抗心律失常、降压及其他活性的N-取代4,5(3)-二苯基-3(5)-吡唑胺类化合物。

Farmaco. 1993 Jul;48(7):967-77.

2

3,5-diphenyl-1H-pyrazole derivatives. XI. N-aryl-5(3)-phenyl-4-(3,5- diphenyl-1-pyrazolyl)-3(5)-pyrazole amines, 5-substituted 4,5-dihydro-3-phenyl-4-(3,5-diphenyl-1-pyrazolyl)-1H-pyrazoles and 2,6-disubstituted 1,6-dihydro-4- phenyl-5-(3,5-diphenyl-1-pyrazolyl)pyrimidines with antipyretic, antiinflammatory and other activities.3,5-二苯基-1H-吡唑衍生物。XI. N-芳基-5(3)-苯基-4-(3,5-二苯基-1-吡唑基)-3(5)-吡唑胺、5-取代的4,5-二氢-3-苯基-4-(3,5-二苯基-1-吡唑基)-1H-吡唑以及具有解热、抗炎和其他活性的2,6-二取代-1,6-二氢-4-苯基-5-(3,5-二苯基-1-吡唑基)嘧啶

Farmaco. 1993 Jul;48(7):949-66.

3

3-(Arylamino)-6,7-dihydro-6-methylpyrano[4,3-c]pyrazol-4(1H or 2H)-ones with antipyretic, analgesic, antiarrhythmic, hypotensive and other activities.具有解热、镇痛、抗心律失常、降压及其他活性的3-（芳基氨基）-6,7-二氢-6-甲基吡喃并[4,3-c]吡唑-4（1H或2H）-酮

Farmaco. 1993 Dec;48(12):1697-708.

4

3,5-Diphenyl-1H-pyrazole derivatives. X. N-substituted 1-(2-aminopropyl)- and 1-(3-amino-2-hydroxypropyl)-3,5-diphenyl-1H-pyrazoles with antiinflammatory and other activities.3,5-二苯基-1H-吡唑衍生物。X. 具有抗炎及其他活性的N-取代的1-(2-氨基丙基)-和1-(3-氨基-2-羟丙基)-3,5-二苯基-1H-吡唑

Farmaco. 1992 Oct;47(10):1235-48.

5

1-Aryl-1H-pyrazole-5-acetic acids with antiinflammatory, analgesic and other activities.具有抗炎、止痛及其他活性的1-芳基-1H-吡唑-5-乙酸

Farmaco. 1994 Feb;49(2):115-9.

6

N-arylsubstituted-1-aryl-3,4-diphenyl-5-pyrazole amines with analgesic and antiarrhythmic properties.具有镇痛和抗心律失常特性的N-芳基取代的1-芳基-3,4-二苯基-5-吡唑胺

Farmaco. 1997 Oct;52(10):615-8.

7

4H-thieno[3,4-c]pyrazole derivatives with antiinflammatory, analgesic, antipyretic and platelet antiaggregating activities.具有抗炎、镇痛、解热和抗血小板聚集活性的4H-噻吩并[3,4-c]吡唑衍生物。

Farmaco. 1992 Dec;47(12):1495-511.

8

3,5-Diphenyl-1H-pyrazole derivatives. IX. 2-substituted 4-phenyl-5-(3,5-diphenyl-1H-pyrazol-1-yl) pyrimidines with platelet antiaggregating and other activities.3,5-二苯基-1H-吡唑衍生物。IX。具有血小板抗聚集及其他活性的2-取代-4-苯基-5-(3,5-二苯基-1H-吡唑-1-基)嘧啶

Farmaco. 1992 Feb;47(2):171-90.

9

Ethyl or methyl 6-substituted 3-(benzoylamino)-2-oxo-2H-pyran-5-carboxylates and 3-(benzoylamino)-7,8-dihydro-2H-1-benzopyran-2,5(6H)-diones with local anesthetic, platelet antiaggregating and other activities.

Farmaco. 1994 Jan;49(1):45-50.

10

3,5-Diphenyl-1H-pyrazole derivatives. VIII. N-substituted 3-(4-hydroxy-3,5-diphenyl-1H-pyrazol-1-yl)-propanamides, -propanamines and 2-(4-hydroxy-3,5-diphenyl-1H-pyrazol-1-yl)ethanamines with platelet antiaggregating, hypotensive, antiarrhythmic and other activities.3,5-二苯基-1H-吡唑衍生物。VIII. N-取代的3-(4-羟基-3,5-二苯基-1H-吡唑-1-基)丙酰胺、丙胺及2-(4-羟基-3,5-二苯基-1H-吡唑-1-基)乙胺，具有抗血小板聚集、降压、抗心律失常及其他活性。

Farmaco. 1991 Mar;46(3):477-99.