玉竹根茎在正常和糖尿病小鼠中的降血糖作用。
Hypoglycemic action of the rhizomes of Polygonatum officinale in normal and diabetic mice.
作者信息
Kato A, Miura T
机构信息
Kobe Women's College of Pharmacy, Japan.
出版信息
Planta Med. 1994 Jun;60(3):201-3. doi: 10.1055/s-2006-959458.
The hypoglycemic effect of the rhizomes of Polygonatum officinale (Liliaceae) was investigated in both normal and streptozotocin-induced diabetic mice. The methanol extract of rhizomes of Polygonatum officinale (PO) (800 mg/kg) reduced the blood glucose of normal mice from 170 +/- 3 to 136 +/- 5 mg/100 ml 4 hours after intraperitoneal administration (P < 0.001), and also significantly lowered the blood glucose of streptozotocin-induced diabetic mice from 696 +/- 60 to 407 +/- 35 mg/100 ml under similar conditions (P < 0.01). PO also suppressed epinephrine-induced hyperglycemia in mice. In addition, the n-butanol fraction of the methanol extract elicited a significant decrease in the blood glucose level of streptozotocin-induced diabetic mice after 4 hours (P < 0.05).
在正常小鼠和链脲佐菌素诱导的糖尿病小鼠中研究了玉竹（百合科）根茎的降血糖作用。玉竹根茎的甲醇提取物（800mg/kg）腹腔注射4小时后，使正常小鼠血糖从170±3mg/100ml降至136±5mg/100ml（P<0.001），在类似条件下也显著降低链脲佐菌素诱导的糖尿病小鼠血糖，从696±60mg/100ml降至407±35mg/100ml（P<0.01）。玉竹还可抑制小鼠肾上腺素诱导的高血糖。此外，甲醇提取物的正丁醇部分在4小时后可使链脲佐菌素诱导的糖尿病小鼠血糖水平显著降低（P<0.05）。
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