Yu L, Ma R, Wang Y, Nishino H
Department of Biochemistry, Shaanxi Provincial Academy of Traditional Chinese Medicine and Pharmacology, Xian.
Planta Med. 1994 Jun;60(3):204-8. doi: 10.1055/s-2006-959459.
Bolbostemma paniculatum (Maxim.) Franquet (Cucurbitaceae) is a traditional Chinese medicinal plant (1), from which tubeimoside 1 was isolated. The antitumor activity and toxicity of tubeimoside 1 was investigated in vivo and in vitro. The results showed that tubeimoside 1 exerts potent anti-tumor activity with low toxicity. The compound inhibited DNA synthesis and induced phenotypic reverse transformation of tumor cells.
雪胆（葫芦科）是一种传统的中国药用植物，从中分离出了雪胆素甲。对雪胆素甲的抗肿瘤活性和毒性进行了体内和体外研究。结果表明，雪胆素甲具有较强的抗肿瘤活性且毒性较低。该化合物抑制DNA合成并诱导肿瘤细胞的表型逆转。
