Prosnitz L R, Goldenberg I S
Cancer. 1975 Jun;35(6):1587-96. doi: 10.1002/1097-0142(197506)35:6<1587::aid-cncr2820350617>3.0.co;2-w.
A treatment program for early stage breast cancer consisting of biopsy only and primary radiation therapy is described. The treatment plan is "radical" with tumoricidal doses or radiation delivered to the breast and axillary, supraclavicular, and internal mammory lymph nodes, i.e. 6000-7000 rads to clinically involved areas and 4500-5000 rads to subclinical disease. Thirty patients have been treated with this program, with followupranging from 1-10 years. Only 1 patient has died from her disease; 1 has had a lot oflocal recurrence readily controlled with mastectomy. Twenty-six patients arealive and well; there have been 3 deaths from intercurrent illness. No significant radiation complications have occurred. Radiation therapy as the sole treatment for breast cancer has been described in the literature for at least 20 years but generally ignored byclinicians. It deserves evaluation as a treatment option in randomized therapeutic trails.
本文描述了一种早期乳腺癌的治疗方案，该方案仅包括活检和原发性放射治疗。治疗计划是“根治性的”，即向乳房、腋窝、锁骨上和乳内淋巴结输送杀肿瘤剂量的辐射，也就是说，对临床受累区域给予6000 - 7000拉德的辐射，对亚临床疾病给予4500 - 5000拉德的辐射。已有30名患者接受了该方案的治疗，随访时间为1至10年。只有1名患者死于该疾病；1名患者出现了大量局部复发，通过乳房切除术很容易得到控制。26名患者存活且状况良好；有3名患者死于并发疾病。未发生明显的放疗并发症。放射治疗作为乳腺癌的唯一治疗方法在文献中已有至少20年的描述，但通常被临床医生忽视。它值得在随机治疗试验中作为一种治疗选择进行评估。
