Weber E, Hellman S
JAMA. 1975 Nov 10;234(6):608-11.
One hundred patients with localized breast carcinoma have been treated by radiation alone from July 1, 1968, until June 30, 1973, at the Joint Center for Radiation Therapy. Patients were referred for many reasons, including changing opinions as to the indications for mastectomy. External beam therapy to the tumor bearing volume and its regional nodal chains has been frequently supplemented by iridium 192 interstitial implantation. Local control has been excellent, particularly in early stage disease. Regionally advanced mammary carcinoma, despite apparently adequate local therapy, demonstrates a rapidly falling survival curve, suggesting the need for early systemic chemotherapy.
1968年7月1日至1973年6月30日期间，100例局限性乳腺癌患者在联合放射治疗中心仅接受了放射治疗。患者因多种原因前来就诊，包括对乳房切除术适应症的看法改变。对肿瘤所在体积及其区域淋巴结链进行的外照射治疗经常辅以铱192组织间植入。局部控制效果极佳，尤其是在疾病早期。区域晚期乳腺癌，尽管局部治疗看似充分，但生存曲线迅速下降，提示需要早期进行全身化疗。
