[恰加斯病患者肾上腺中央静脉的急性期反应与寄生虫感染]

[Acute-phase reaction and parasitism in the central adrenal vein in Chagas' disease patients].

作者信息

da Cunha D F, Vieira C de O, de Paula e Silva G, Erédia G R, Teixeira V de P

机构信息

Disciplina de Nutrologia, Faculdade de Medicina do Triângulo Mineiro (FMTM), Uberaba, MG.

出版信息

Rev Soc Bras Med Trop. 1994 Apr-Jun;27(2):83-6. doi: 10.1590/s0037-86821994000200005.

DOI:10.1590/s0037-86821994000200005

PMID:8073156

Abstract

The systemic reaction to severe trauma and/or infection, acute phase response (APR), are often associated with immunosuppression and reactivation of chronic latent infection. Our main purpose was to verify, in a group of 71 autopsied chronic chagasic with or without APR, the frequency of T. cruzi nests in the central vein of adrenal gland (CVAG). APR, defined by: 1) death secondary to sepsis and/or trauma plus, 2) bleeding stress gastric ulcerations or 3) spleen reactional state or 4) liver steatosis, was observed in 30 chronic chagasic (APR+). Weight, height and body mass index (BMI) were obtained. APR(+) chronic chagasic had worse nutritional status than APR(-) ones: weight = 49.0 vs 54.5 kg; BMI = 17.5 vs 20.6 kg/m2 (median p < 0.05). CVAG T. cruzi nests frequency were similar (43.3% and 43.9%, respectively) between both Groups. We conclude that APR(+) chronic chagasic had worse nutritional status than APR(-) ones, and that APR development did not change the CVAG T. cruzi nests frequency.

摘要

对严重创伤和/或感染的全身反应，即急性期反应（APR），常与免疫抑制及慢性潜伏感染的重新激活相关。我们的主要目的是在一组71例经尸检的慢性恰加斯病患者（有或无APR）中，核实肾上腺中央静脉（CVAG）中克氏锥虫巢的出现频率。APR的定义为：1）因败血症和/或创伤继发死亡，加上2）应激性胃溃疡出血，或3）脾脏反应状态，或4）肝脂肪变性，在30例慢性恰加斯病患者（APR+）中观察到。获取了体重、身高和体重指数（BMI）。APR（+）慢性恰加斯病患者的营养状况比APR（-）患者更差：体重分别为49.0千克和54.5千克；BMI分别为17.5和20.6千克/平方米（中位数，p<0.05）。两组之间CVAG克氏锥虫巢的出现频率相似（分别为43.3%和43.9%）。我们得出结论，APR（+）慢性恰加斯病患者的营养状况比APR（-）患者更差，并且APR的发生并未改变CVAG克氏锥虫巢的出现频率。