Fukaya T, Sugawara J, Yoshida H, Yajima A
Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan.
Tohoku J Exp Med. 1994 Mar;172(3):221-6. doi: 10.1620/tjem.172.221.
Macrophage colony stimulating factor (M-CSF) concentrations in the peritoneal fluid of 44 infertile patients were measured. The concentration of M-CSF was significantly higher in the patients with endometriosis than in those without endometriosis. There was no significant difference between the M-CSF concentration and stage of endometriosis classified by revised American Fertility Society (rAFS) classification in the 44 patients. However, in primary infertility patients with endometriosis there was a significant correlation between peritoneal M-CSF levels and rAFS points of endometriosis. We speculate that there is some relationship between the increased levels of M-CSF in the peritoneal cavity and the primary infertility associated with endometriosis especially progression of endometriosis.
对44例不孕患者的腹腔液中巨噬细胞集落刺激因子（M-CSF）浓度进行了测定。子宫内膜异位症患者腹腔液中M-CSF浓度显著高于非子宫内膜异位症患者。在这44例患者中，M-CSF浓度与根据美国生殖医学学会修订版（rAFS）分类的子宫内膜异位症分期之间无显著差异。然而，在原发性子宫内膜异位症不孕患者中，腹腔M-CSF水平与子宫内膜异位症的rAFS评分之间存在显著相关性。我们推测，腹腔内M-CSF水平升高与子宫内膜异位症相关的原发性不孕尤其是子宫内膜异位症进展之间存在某种关联。
