Kim C Y, Wakabayashi K, Nobunaga T
Institute for Experimental Animals, Tohoku University School of Medicine, Sendai, Japan.
Tohoku J Exp Med. 1994 Mar;172(3):237-42. doi: 10.1620/tjem.172.237.
Time-dependent ovulation-blocking effect of ether anesthesia was investigated using female Wistar-Imamichi rats showing a 4-day cycling rhythm. A 6-hr (1400-2000) and 8-hr (1400-2200) anesthesia with ether vapor on proestrus caused ovulation blockade in 85% and 100% of the rats, respectively. On the other hand, pentobarbital injections at 1400 and 1500 completely blocked the spontaneous ovulation, while the injections at 1600 and 1700 did not. Ether (1400-2000) and pentobarbital anesthesia decreased the mean serum LH levels at 2000 on proestrus. The LH levels were 13.26 ng/ml for the control, 0.36 ng/ml for the ether group and 0.56 ng/ml for the pentobarbital group, respectively. These findings indicated that ether and pentobarbital similarly suppressed the LH surge, but difference between ovulation-blocking effects by ether and pentobarbital is possibly due to factor(s) other than suppression of the LH surge.
利用表现出4天周期节律的雌性Wistar-Imamichi大鼠研究了乙醚麻醉的时间依赖性排卵阻断作用。在发情前期，用乙醚蒸汽进行6小时（14:00-20:00）和8小时（14:00-22:00）麻醉，分别导致85%和100%的大鼠排卵受阻。另一方面，在14:00和15:00注射戊巴比妥可完全阻断自发排卵，而在16:00和17:00注射则不能。乙醚（14:00-20:00）和戊巴比妥麻醉降低了发情前期20:00时的平均血清促黄体生成素（LH）水平。对照组的LH水平为13.26 ng/ml，乙醚组为0.36 ng/ml，戊巴比妥组为0.56 ng/ml。这些发现表明，乙醚和戊巴比妥同样抑制LH峰，但乙醚和戊巴比妥的排卵阻断作用之间的差异可能归因于LH峰抑制以外的因素。
