Jacobs D E, Arakawa A, Courtney C H, Gemmell M A, McCall J W, Myers G H, Vanparijs O
Department of Pathology and Infectious Diseases, Royal Veterinary College, University of London, North Mymms, Hatfield, UK.
Vet Parasitol. 1994 Apr;52(3-4):179-202. doi: 10.1016/0304-4017(94)90110-4.
Guidelines have been designed to assist in the planning, operation and interpretation of studies for the assessment of the efficacy of drugs against helminth parasites of dogs and cats. The advantages, disadvantages and application of critical and controlled tests are presented. Information is also provided on the selection of animals, housing, feeding, dose-titration, confirmatory and clinical trials, record keeping and necropsy procedures. These guidelines should assist both investigators and registration authorities involved in the evaluation of anthelmintics to employ comparable and standard procedures and will have the added benefit of minimising the numbers of animals needed for such tests.
本指南旨在协助规划、开展和解读用于评估药物抗犬猫蠕虫寄生虫疗效的研究。文中介绍了关键试验和对照试验的优缺点及应用。还提供了有关动物选择、饲养、喂食、剂量滴定、确证试验和临床试验、记录保存及尸检程序的信息。这些指南应有助于参与驱虫药评估的研究人员和注册机构采用可比的标准程序,还有助于减少此类试验所需的动物数量。