Yazwinski T A, Chapman H D, Davis R B, Letonja T, Pote L, Maes L, Vercruysse J, Jacobs D E
Department of Animal Science, University of Arkansas, Fayetteville, AR 72701, USA.
Vet Parasitol. 2003 Oct 8;116(2):159-73. doi: 10.1016/s0304-4017(03)00264-4.
These guidelines have been prepared to assist in the planning, operation and interpretation of studies designed to assess the effectiveness of drugs against helminth parasites of chickens and turkeys. They are the first to be compiled under the auspices of the World Association for the Advancement of Veterinary Parasitology (WAAVP) for these parasites. The advantages and disadvantages of the widely used critical and controlled tests are discussed. Information is provided on the selection of animals for experiments, animal housing, feed, dose determination studies, confirmatory and field trials, record keeping and necropsy procedures. This document should help investigators and those involved in product approval and registration in conducting and evaluating studies concerned with determining the effectiveness and safety of anthelmintic drugs.
编写这些指南是为了协助规划、开展和阐释旨在评估药物抗鸡和火鸡体内蠕虫寄生虫有效性的研究。这是世界兽医寄生虫学促进会(WAAVP)主持编写的针对这些寄生虫的首批指南。文中讨论了广泛使用的关键试验和对照试验的优缺点。提供了关于实验动物选择、动物饲养、饲料、剂量确定研究、验证性试验和田间试验、记录保存以及尸检程序等方面的信息。本文件应有助于研究人员以及参与产品批准和注册的人员开展和评估有关确定驱虫药有效性和安全性的研究。