卡介苗增强环磷酰胺诱导的免疫抑制作用
[BCG potentiates the immunodepression induced by cyclophosphamide].
作者信息
Mathé G, Halle-Pannenko O, Bourut C
出版信息
C R Acad Hebd Seances Acad Sci D. 1975 Apr 14;280(14):1749-51.
PMID:807370
Abstract
Compared to the effect of CPM alone, the survival of allogeneic C3H skin grafts on Fl (DBA/2 X C57Bl/6) recipients is considerably enhanced when the recipient is given BCG (1 mg/mouse) 14 days before the graft and CPM (80 or 134 mg/kg) one day after the graft. While other mechanisms cannot be entirely excluded, it is possible that BCG stimulates the lymphocytes to enter the cell cycle, which makes them more sensitive to CPM, a cycle-dependent agent.
摘要
与单纯使用环磷酰胺（CPM）的效果相比，当在移植前14天给受体注射卡介苗（BCG，1毫克/只小鼠），并在移植后一天注射环磷酰胺（80或134毫克/千克）时，同种异体C3H皮肤移植物在Fl（DBA/2×C57Bl/6）受体上的存活时间显著延长。虽然不能完全排除其他机制，但卡介苗有可能刺激淋巴细胞进入细胞周期，这使得它们对环磷酰胺这种依赖细胞周期的药物更加敏感。
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