Zhiburt E B, Boĭchak M P, Volchek I V, Abbasaliev E A, Iakovlev E A, Perfilov A M
Lik Sprava. 1994 Feb(2):73-6.
As many as 159 patients with pneumonia (all men aged 18-39) were examined. Functional activity of monocytes was studied in an integral test with nitroblue tetrazolium as was nonspecific cellular antiviral resistance by the level of viral damage to the monocytes and lymphocytes. The progression of pneumonia was found to be accompanied by a decrease in the number of phagocytizing mononuclears and the activity of phagocytosis. Nonspecific cellular antiviral resistance is significantly impaired. The proportion of monocytes and lymphocytes containing viral inclusions increases several-fold. The treatment of patients is accompanied by positive dynamics of indicators of functional status of monocytes and nonspecific cellular antiviral resistance. By the time of discharge from hospital the impaired functions of immunocompetent cells fail to completely restore.
对多达159例肺炎患者（均为18 - 39岁男性）进行了检查。采用硝基蓝四氮唑积分试验研究单核细胞的功能活性，并通过单核细胞和淋巴细胞的病毒损伤水平研究非特异性细胞抗病毒抵抗力。发现肺炎进展伴随着吞噬单核细胞数量的减少和吞噬作用活性的降低。非特异性细胞抗病毒抵抗力明显受损。含有病毒包涵体的单核细胞和淋巴细胞比例增加了几倍。患者的治疗伴随着单核细胞功能状态指标和非特异性细胞抗病毒抵抗力的积极变化。到出院时，免疫活性细胞受损的功能未能完全恢复。
