[猿猴冠状病毒的特性]

[The properties of simian coronavirus].

作者信息

Goncharuk E I, Shevtsova Z V, Rumel' N B, Fedorinov V V

出版信息

Vopr Virusol. 1993 May-Jun;38(3):126-9.

Abstract

Properties of 20 coronavirus (CV) isolates obtained from spontaneously infected Papio hamadryas and rhesus monkeys were investigated. Two of them were selected as simian CV prototype strains-CVRM 281 (rhesus monkey) and CVP 250 (Papio hamadryas), and can be offered as candidates to the Coronaviridae family. They are closely related to each other, but differ in some biological properties and polypeptides. These strains belong to the 2nd antigen group of mammalian CV with the prototype strain HCV OC 43 but differ from the latter. The strain CVRM 281 induces experimental CV infection which can be used as a model for investigations of some obscure aspects of human infection. The properties of these viruses suggest their usefulness for diagnostic purposes.

摘要

对从自然感染的阿拉伯狒狒和恒河猴中获得的20株冠状病毒（CV）分离株的特性进行了研究。其中两株被选为猿猴CV原型株——CVRM 281（恒河猴）和CVP 250（阿拉伯狒狒），可作为冠状病毒科的候选毒株。它们彼此密切相关，但在一些生物学特性和多肽方面存在差异。这些毒株属于哺乳动物CV的第2抗原组，以HCV OC 43为原型株，但与后者不同。CVRM 281株可诱导实验性CV感染，可作为研究人类感染某些不明方面的模型。这些病毒的特性表明它们可用于诊断目的。