Goncharuk E I, Shevtsova Z V, Krylova R I, Rumel' N B, Stetsenko V I
Mikrobiol Z. 1994 May-Jun;56(3):65-71.
The coronavirus (CV) infection has been reproduced on monkeys (Macaca mulatta) for the first time. The strain CVRM 281, obtained from rhesus monkey who died of the spontaneous CV injection, has been used for the infection. The experimental CV infection has a chronic current with periodical relapses and virus persistence. Gastrointestinal tract (enterocolitis) and respiratory tract (pneumonia) are damaged exhibiting characteristic histological lesions. The monkey model of the CV injection can be used to solve obscure questions of human one.
冠状病毒(CV)感染首次在恒河猴(猕猴)身上再现。从死于自发性CV感染的恒河猴身上获取的毒株CVRM 281被用于感染实验。实验性CV感染呈慢性病程,伴有周期性复发和病毒持续存在。胃肠道(小肠结肠炎)和呼吸道(肺炎)受损,呈现出特征性的组织学病变。CV感染的猴子模型可用于解决人类CV感染中尚不明确的问题。