Igarashi K, Mitani H, Adachi H, Shinoda H
Department of Orthodontics, Tohoku University, Dental School, Sendai, Japan.
Am J Orthod Dentofacial Orthop. 1994 Sep;106(3):279-89. doi: 10.1016/S0889-5406(94)70048-6.
The purpose of this study was to examine the effect of 4-amino-1-hydroxybutylidene-1,1-bisphosphonate (AHBuBP), a potent blocker of bone resorption, on orthodontic tooth movements in rats. In the first experiment, the right and left upper first molars were moved buccally for 3 weeks with a uniform standardized expansion spring under systemic administration of AHBuBP every other day. The total tooth movement during the 3-week experimental period was 40% of that in the control at a dose of 0.5 mg P/kg. In the second experiment, the right and left upper first molars were first moved buccally for 3 weeks without AHBuBP. The spring was then removed and administration of AHBuBP was initiated. The total relapse movement during the 3-week experimental period was 50% of that in the control at a dose of 0.5 mg P/kg. Results of the first and second experiments were both dose dependent. Histologic examination showed that in the experimental animals fewer osteoclasts appeared on the alveolar bone surface, and both bone resorption and root resorption were inhibited. Inhibition of tooth movement was also observed when AHBuBP was applied topically. These results suggest that AHBuBP could be useful in enhancing anchorage or retaining teeth in orthodontic treatment.
本研究的目的是检测强效骨吸收阻滞剂4-氨基-1-羟基亚丁基-1,1-双膦酸盐（AHBuBP）对大鼠正畸牙齿移动的影响。在第一个实验中，在每隔一天全身给予AHBuBP的情况下，使用均匀标准化的扩展弹簧将左右上颌第一磨牙颊向移动3周。在剂量为0.5mg P/kg时，3周实验期内的牙齿总移动量为对照组的40%。在第二个实验中，左右上颌第一磨牙首先在不使用AHBuBP的情况下颊向移动3周。然后移除弹簧并开始给予AHBuBP。在剂量为0.5mg P/kg时，3周实验期内的总复发移动量为对照组的50%。第一个和第二个实验的结果均呈剂量依赖性。组织学检查显示，在实验动物中，牙槽骨表面出现的破骨细胞较少，骨吸收和牙根吸收均受到抑制。局部应用AHBuBP时也观察到牙齿移动受到抑制。这些结果表明，AHBuBP在正畸治疗中增强支抗或保持牙齿方面可能有用。
