Adachi H, Igarashi K, Mitani H, Shinoda H
Department of Orthodontics and Pharmacology, School of Dentistry, Tohoku University, Sendai, Japan.
J Dent Res. 1994 Aug;73(8):1478-86. doi: 10.1177/00220345940730081301.
In orthodontics, undesirable movement of anchor teeth during tooth movement and relapse of moved teeth after treatment are the main causes of unsuccessful results. If these tooth movements could be prevented with pharmacological agents, a less complex orthodontic force system and less extensive retention would be required. The purpose of this study was to examine the effect of topical administration of a bisphosphonate (risedronate), a potent blocker of bone resorption, on orthodontic tooth movements in rats. In the first experiment, both the right and left upper first molars were moved buccally with a standardized expansion spring under administration of risedronate. Risedronate solution was injected into the subperiosteum area adjacent to the left upper first molar. The right first molar served as a control with an injection of 0.9% NaCl solution. The topical administration of risedronate caused a significant and dose-dependent reduction of tooth movement after the orthodontic force was applied. In the second experiment, the right and left upper molars were first moved buccally for three weeks. The spring was then removed, and administration of risedronate was begun. The topical administration of risedronate inhibited relapse of the tooth in a dose-dependent manner. The administration of risedronate did not affect either overall growth of the animals or longitudinal growth of tibiae. These results suggest that topical application of risedronate may be helpful in anchoring and retaining teeth under orthodontic treatment.
在正畸治疗中，牙齿移动过程中支抗牙的不良移动以及治疗后移动牙齿的复发是导致治疗效果不佳的主要原因。如果能够使用药物制剂预防这些牙齿移动，那么就需要一个不太复杂的正畸力系统以及不太广泛的保持措施。本研究的目的是研究局部应用双膦酸盐（利塞膦酸盐）（一种强效的骨吸收阻滞剂）对大鼠正畸牙齿移动的影响。在第一个实验中，在给予利塞膦酸盐的情况下，使用标准化的扩弓弹簧将左右上颌第一磨牙颊向移动。将利塞膦酸盐溶液注射到左上颌第一磨牙相邻的骨膜下区域。右侧第一磨牙作为对照，注射0.9%的氯化钠溶液。在施加正畸力后，局部应用利塞膦酸盐导致牙齿移动显著且呈剂量依赖性减少。在第二个实验中，首先将左右上颌磨牙颊向移动三周。然后移除弹簧，并开始给予利塞膦酸盐。局部应用利塞膦酸盐以剂量依赖性方式抑制牙齿复发。利塞膦酸盐的应用既不影响动物的整体生长，也不影响胫骨的纵向生长。这些结果表明，局部应用利塞膦酸盐可能有助于正畸治疗中牙齿的锚定和保持。
