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[镧与蝎毒对离体豚鼠回肠的作用]

[Lanthanum and scorpion venom on the isolated guinea pig ileum].

作者信息

Tazieff-Depierre F, Goudou D, Métézeau P, Prévot A R

出版信息

C R Acad Hebd Seances Acad Sci D. 1975 May 26;280(20):2385-8.

PMID:807428
Abstract

In the guinea-pig isolated ileum, lanthanum increases the quantity of spontaneously released acetylcholine and induces contracture of this muscle. We have shown that the latter phenomenon is not a consequence of the former. We conclude that it could be due to the Ca++ displaced by La+++. The scorpion venom effects are abolished by lanthanum. We explain this observation by blockage of Ca++ fluxes.

摘要

在豚鼠离体回肠中,镧可增加自发释放的乙酰胆碱的量,并引起该肌肉的挛缩。我们已经表明,后一种现象并非前一种现象的结果。我们得出结论,这可能是由于La+++取代了Ca++所致。镧可消除蝎毒的作用。我们通过阻断Ca++通量来解释这一观察结果。

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