Amarenco P, Cohen A
Service de Neurologie, Hôpital Saint-Antoine, Paris.
Ann Cardiol Angeiol (Paris). 1994 May;43(5):278-81.
Atherosclerosis of the aortic arch is common in individuals aged over 60. Plaques are very often ulcerated. The normal healing process results in the regular formation of thrombi on these ulcerations. A mural thrombus can thus be the source of systemic or cerebral emboli. Since the advent of transesophageal echocardiography, it has become possible to detect atherosclerotic plaques of the aortic arch. However, a causal relationship has never been demonstrated and it is possible that they may merely be a marker of atherosclerotic disease. Certain arguments suggest that the aortic arch may be a source of cerebral emboli: the high incidence of aortic mural thrombi and atheroma emboli during aortography or coronary arteriography, or cardiac surgery with extracorporeal circulation requiring cannulation of the aorta. Recent studies have also shown that plaques of the aortic arch are commoner in cases of cerebral infarction of unknown origin than when another potential cause is detected. The natural history of this type of lesion must be studied before any management attitude can be defined. In the present state of knowledge, the only possible advice is antiplatelet treatment and case-by-case consideration of anti-coagulant treatment, in particular in the presence of a mobile thrombus of the aortic arch.
主动脉弓粥样硬化在60岁以上人群中很常见。斑块常常发生溃疡。正常的愈合过程会导致这些溃疡处经常形成血栓。因此,附壁血栓可能是全身或脑栓塞的来源。自从经食管超声心动图问世以来,已能够检测到主动脉弓的动脉粥样硬化斑块。然而,从未证实存在因果关系,它们可能仅仅是动脉粥样硬化疾病的一个标志物。某些论据表明主动脉弓可能是脑栓塞的一个来源:主动脉造影或冠状动脉造影期间,或需要对主动脉插管进行体外循环的心脏手术中,主动脉附壁血栓和动脉粥样硬化栓子的发生率很高。最近的研究还表明,在不明原因的脑梗死病例中,主动脉弓斑块比发现其他潜在病因时更为常见。在确定任何治疗方案之前,必须先研究这类病变的自然病程。就目前的知识水平而言,唯一可行的建议是抗血小板治疗,并根据具体情况考虑抗凝治疗,特别是在存在主动脉弓活动血栓的情况下。