Ebert W, Knoch H, Werle B, Trefz G, Muley T, Spiess E
Thoraxklinik der LVA Baden, Heidelberg-Rohrbach, Germany.
Anticancer Res. 1994 May-Jun;14(3A):895-9.
In the study of 65 matched pairs of lung tumor tissue and normal lung parenchyma, cathepsin B (CB) activity was found to be increased about 4.6-fold, when regarding median levels. CB activity was found to be insignificantly higher in adenocarcinoma compared to the other histologic cell types. CB levels did not correlate with tumor stages (TNM) nor with cell differentiation, while increased CB activity was related to shorter survival rates of the patients. It is concluded that lung tumor CB is of some prognostic value for the outcome of the malignant disease.
在对65对匹配的肺肿瘤组织和正常肺实质进行的研究中，若考虑中位数水平，发现组织蛋白酶B（CB）活性增加了约4.6倍。与其他组织学细胞类型相比，腺癌中的CB活性虽有升高但无显著差异。CB水平与肿瘤分期（TNM）及细胞分化均无相关性，然而CB活性增加与患者较短的生存率相关。结论是，肺肿瘤CB对恶性疾病的预后具有一定的预测价值。
