实验性诱导和自发性尿毒症犬体内疑似尿毒症毒素物质的血浆浓度。

Plasma concentrations of substances suspected as uremic toxins in experimentally induced and spontaneous uremic dogs.

作者信息

Kawamura M, Ohashi F, Nishimura R, Sasaki N, Takeuchi A

机构信息

Department of Veterinary Surgery, Faculty of Agriculture, University of Tokyo, Japan.

出版信息

J Vet Med Sci. 1994 Apr;56(2):381-3. doi: 10.1292/jvms.56.381.

DOI:10.1292/jvms.56.381

PMID:8075231

Abstract

Plasma concentrations of four substances, a pyridine derivative (S7a), uric acid (UA), hippuric acid (HA) and kynurenic acid (KA), suspected as uremic toxins in dogs were determined in dogs with experimentally induced uremia by the ligations of renal arteries, spontaneous uremic dog patients and normal dogs. In experimentally induced uremic dogs, plasma concentrations of S7a, HA and KA showed continuous increase after the ligation of renal arteries together with a significant correlation to plasma creatinine concentration (Cre). Plasma UA concentration increased rapidly, but it showed a varying fluctuation without showing any correlation to Cre. Plasma concentrations of S7a, UA, HA and KA in spontaneous uremic dogs were almost within the ranges of those of experimentally induced uremic dogs.

摘要

在通过结扎肾动脉诱导实验性尿毒症的犬、自发性尿毒症犬患者和正常犬中，测定了四种被怀疑为犬尿毒症毒素的物质——一种吡啶衍生物（S7a）、尿酸（UA）、马尿酸（HA）和犬尿酸（KA）的血浆浓度。在实验性诱导的尿毒症犬中，肾动脉结扎后S7a、HA和KA的血浆浓度持续升高，且与血浆肌酐浓度（Cre）显著相关。血浆UA浓度迅速升高，但呈现出波动变化，与Cre无相关性。自发性尿毒症犬中S7a、UA、HA和KA的血浆浓度几乎在实验性诱导的尿毒症犬的范围内。