Bondarenko D I, Dedukhova V I, Mokhova E N
Biokhimiia. 1994 Jun;59(6):911-5.
The uncoupling effect of 2-hexadecylmalonic acid (HDMA) and 2-tetradecylmalonic acid (TDMA), the dicarboxylic derivatives of stearic and palmitic acids, have been studied in heart mitochondria. The effects of these compounds and related fatty acids on the induced by ascorbate oxidation with PMS (or TMPD) in the presence of oligomycin, phosphate and rotenone have been compared. It was found that both HDMA and TDMA uncoupled mitochondria with a similar efficiency as did the corresponding fatty acids, while the uncoupling effect of low concentrations of HDMA and TDMA were almost completely suppressed by carboxyatractylate.
已在心脏线粒体中研究了硬脂酸和软脂酸的二羧酸衍生物2-十六烷基丙二酸（HDMA）和2-十四烷基丙二酸（TDMA）的解偶联作用。比较了这些化合物及相关脂肪酸对在寡霉素、磷酸盐和鱼藤酮存在的情况下由抗坏血酸与PMS（或TMPD）氧化所诱导的作用。结果发现，HDMA和TDMA解偶联线粒体的效率与相应脂肪酸相似，而低浓度HDMA和TDMA的解偶联作用几乎完全被羧基苍术苷抑制。
