Dedukhova V I, Mokhova E N, Starkov A A
A.N. Belozersky Institute of Physical-Chemical Biology, Moscow State University, Russia.
Biochem Mol Biol Int. 1993 Aug;30(6):1161-7.
The effect of TPP+ on the fatty acid or FCCP-induced uncoupling in rat heart mitochondria was studied. It was found that (a) TPP+ increases the stimulation of oxygen consumption by palmitic acid or FCCP in the presence of oligomycin, (b) TPP+ greatly enhances the palmitic acid or FCCP-induced delta psi decrease. Both effects of TPP+ were strongly suppressed by carboxyatractylate in the case of palmitate but were not in the case of FCCP. The role of ATP/ADP-antiporter in the TPP+ and palmitic acid effects is discussed.
研究了TPP⁺对大鼠心脏线粒体中脂肪酸或FCCP诱导的解偶联作用的影响。结果发现：(a) 在存在寡霉素的情况下，TPP⁺增强了棕榈酸或FCCP对氧消耗的刺激作用；(b) TPP⁺极大地增强了棕榈酸或FCCP诱导的Δψ降低。对于棕榈酸，TPP⁺的这两种作用均被羧基苍术苷强烈抑制，但对于FCCP则不然。讨论了ATP/ADP反向转运体在TPP⁺和棕榈酸作用中的作用。
