Rubio M, Sánchez F, Carretero J, Riesco J M, Cabo L, Vázquez R
Department of Human Anatomy and Histology, Faculty of Medicine, University of Salamanca, Spain.
Histol Histopathol. 1994 Apr;9(2):221-6.
In order to test the possible effect of chronic treatment with met-enkephalin upon the LH-adenohypophyseal cells, an immunohistochemical-morphometric study was carried out in rats of both sexes receiving a daily dose of 40 micrograms of met-enkephalin intramuscularly over 15 days. Following the administration of the opioid, a drastic decrease in the cellular, cytoplasmic and nuclear areas when compared to the normal and control animals was detected. Morphologically, the main finding in males was the appearance of irregularly-shaped pseudovacuolated cells. On the other hand, in females a decrease in the intensity of reaction was found. These results strongly suggest a decrease in the activity of the LH-adenohypophyseal cells following chronic administration of met-enkephalin.
为了测试甲硫氨酸脑啡肽长期治疗对促黄体生成素 - 腺垂体细胞的可能影响，对雌雄大鼠进行了一项免疫组织化学 - 形态计量学研究，这些大鼠连续15天每天肌肉注射40微克甲硫氨酸脑啡肽。给予阿片类药物后，与正常和对照动物相比，细胞、细胞质和细胞核面积急剧减少。在形态学上，雄性的主要发现是出现不规则形状的假空泡细胞。另一方面，在雌性中发现反应强度降低。这些结果强烈表明，长期给予甲硫氨酸脑啡肽后促黄体生成素 - 腺垂体细胞的活性降低。
