Marks-Kończalik J, Rozniecki J
Kliniki Pneumonologii i Alergologii IMW AM w Lodzi.
Pneumonol Alergol Pol. 1994;62(1-2):18-23.
In 78 patients with pulmonary emphysema (49 smokers, 29 nonsmokers) urinary desmosine excretion (UDE) and neutrophil elastase activity (NE) were evaluated. UDE and NE were similar in smokers and nonsmokers and significantly higher than in age, sex-matched control groups. UDE correlated better with NE in nonsmokers than in smokers. Cigarette smoking did not effect UDE in patients with pulmonary emphysema. Obtained results indicate, that UDE measurement could be used in diagnosis and monitoring of lung elastolysis in pulmonary emphysema and suggest the key role of neutrophil elastase in pathogenesis of this disorder.
对78例肺气肿患者（49例吸烟者，29例不吸烟者）的尿去甲基胶原吡啶交联排泄量（UDE）和中性粒细胞弹性蛋白酶活性（NE）进行了评估。吸烟者和不吸烟者的UDE和NE相似，且显著高于年龄、性别匹配的对照组。与吸烟者相比，不吸烟者的UDE与NE的相关性更好。吸烟对肺气肿患者的UDE没有影响。所得结果表明，UDE测量可用于肺气肿肺弹性蛋白溶解的诊断和监测，并提示中性粒细胞弹性蛋白酶在该疾病发病机制中的关键作用。
