Bridges R B, Fu M C, Rehm S R
Eur J Respir Dis. 1985 Aug;67(2):84-93.
Neutrophils from 49 young male smokers contained significantly higher myeloperoxidase (MPO) activity than those from 49 age-matched, nonsmoking controls, while the elastase-like activity was not different in the two populations. MPO activity was increased in some smokers, but did not correlate significantly with the increased number of peripheral blood neutrophils, cigarette usage (present or cumulative), or the mild pulmonary dysfunction detected by forced expiratory spirometry and the single breath nitrogen test. This increased MPO activity in smokers' neutrophils may contribute to the greater risk of obstructive pulmonary disease in some smokers by an exacerbation of the protease-antiprotease imbalance in the lung. This hypothesis is supported by the prior observations that neutrophils are recruited in greater numbers into the lungs of smokers and that MPO (in the presence of H2O2 and chloride ion) oxidatively inactivates antiproteases of both the alveoli and the mucus-lined airways.
49名年轻男性吸烟者的中性粒细胞所含髓过氧化物酶（MPO）活性显著高于49名年龄匹配的非吸烟对照者，而这两组人群的类弹性蛋白酶活性并无差异。部分吸烟者的MPO活性有所增加，但与外周血中性粒细胞数量增加、吸烟量（当前或累积），或通过用力呼气肺活量测定和单次呼吸氮试验检测到的轻度肺功能障碍均无显著相关性。吸烟者中性粒细胞中MPO活性增加，可能通过加剧肺部蛋白酶 - 抗蛋白酶失衡，导致部分吸烟者患阻塞性肺病的风险更高。先前的观察结果支持这一假说，即吸烟者肺部募集了更多数量的中性粒细胞，且MPO（在过氧化氢和氯离子存在的情况下）可氧化灭活肺泡和黏液衬里气道中的抗蛋白酶。
