[高剂量雾化吸入异丙托溴铵对慢性阻塞性肺疾病和支气管哮喘患者肺通气功能的影响]

[Effect of vaporizing high doses of ipratropium bromide on lung ventilation in patients with chronic obstructive pulmonary disease and bronchial asthma].

作者信息

Dor A, Krasnowska M, Małolepszy J

机构信息

Katedry i Kliniki Chorób Wewnetrznych i Alergologii AM we Wrocławiu.

出版信息

Pneumonol Alergol Pol. 1994;62(1-2):75-9.

PMID:8075617

Abstract

Authors compared efficacy of high Atrovent doses and Salbutamol on pulmonary ventilation. Examinations were performed in 20 patients with BA and 20 patients with COPD. Each drug was given on separate days in increasing doses (0.04; 0.25 and 0.5 mg) of Atrovent and 0.2 mg of Salbutamol. Bronchodilatation was assessed by measurement of FEV1; FEF25%, FEF50%, FEF75%. Maximal effect in patients with COPD was reached with doses of 0.25 and 0.5 mg of Atrovent (delta FEV1(%) +22). Salbutamol and 0.04 mg of Atrovent were significantly less effective. In patients with BA Salbutamol (delta FEV1(%) +49) are likely to be more effective bronchodilator an Atrovent (delta FEV1(%) +26).

摘要

作者比较了高剂量异丙托溴铵和沙丁胺醇对肺通气的疗效。对20例哮喘患者和20例慢性阻塞性肺疾病（COPD）患者进行了检查。每种药物在不同日期分别给予递增剂量（0.04、0.25和0.5毫克）的异丙托溴铵以及0.2毫克的沙丁胺醇。通过测量第一秒用力呼气容积（FEV1）、25%用力呼气流量（FEF25%）、50%用力呼气流量（FEF50%）和75%用力呼气流量（FEF75%）来评估支气管扩张情况。COPD患者使用0.25毫克和0.5毫克异丙托溴铵时达到最大效果（FEV1变化百分比（%）+22）。沙丁胺醇和0.04毫克异丙托溴铵的效果明显较差。在哮喘患者中，沙丁胺醇（FEV1变化百分比（%）+49）可能是比异丙托溴铵（FEV1变化百分比（%）+26）更有效的支气管扩张剂。