Goldberger B A, Cone E J
Chemistry and Drug Metabolism Section, National Institute on Drug Abuse, Baltimore, MD 21224.
J Chromatogr A. 1994 Jul 15;674(1-2):73-86. doi: 10.1016/0021-9673(94)85218-9.
The Mandatory Guidelines for Federal Workplace Drug Testing Programs require the use of gas chromatography-mass spectrometry (GC-MS) for the confirmation of presumptive positive urine specimens. This review focuses upon GC-MS methods developed specifically for forensic confirmation of amphetamine, methamphetamine, 11-nor-delta 9-tetrahydrocannabinol-9-carboxylic acid (THC-acid), benzoylecgonine, morphine, codeine and phencyclidine in urine for purposes of workplace drug testing. In addition, current laboratory issues pertaining to each drug class are reviewed. Generally, drug assays utilized either liquid-liquid or solid-phase extraction methods, derivatization if necessary, and GC-MS detection operating in the selected ion monitoring mode or by full scan acquisition.
《联邦工作场所药物检测计划强制指南》要求使用气相色谱 - 质谱联用仪（GC-MS）来确证尿液样本初步呈阳性的结果。本综述着重于专门为工作场所药物检测而开发的GC-MS方法，这些方法用于确证尿液中的苯丙胺、甲基苯丙胺、11-去甲-Δ9-四氢大麻酚-9-羧酸（THC-酸）、苯甲酰爱康宁、吗啡、可待因和苯环己哌啶。此外，还综述了与各类药物相关的当前实验室问题。一般来说，药物分析采用液 - 液萃取或固相萃取方法，必要时进行衍生化，并采用在选择离子监测模式下运行或通过全扫描采集的GC-MS检测。
