用于尿液中药物分析的RapiTest与Emit d.a.u.及气相色谱-质谱联用仪的比较。

Comparison of RapiTest with Emit d.a.u. and GC-MS for the analysis of drugs in urine.

作者信息

Korte T, Pykäläinen J, Lillsunde P, Seppälä T

机构信息

National Public Health Institute, Laboratory of Pharmacology and Toxicology, Helsinki, Finland.

出版信息

J Anal Toxicol. 1997 Jan-Feb;21(1):49-53. doi: 10.1093/jat/21.1.49.

DOI:10.1093/jat/21.1.49

PMID:9013293

Abstract

Results obtained with RapiTest THC (One Step delta 9-Tetrahydrocannabinol Test), RapiTest MOP (One Step Morphine Test), RapiTest MET (One Step Methamphetamine Test), and RapiTest COC (One Step Cocaine Test) were compared with the results obtained with Emit d.a.u. and with gas chromatographic-mass spectrometric (GC-MS) methods. In all, 81 urine samples taken from specimens submitted for routine analysis in the Laboratory of Pharmacology and Toxicology were analyzed. Samples were screened with Emit, reanalyzed by RapiTests, and quantitated using GC-MS methods. Both positive and negative urine samples were tested. The results obtained with RapiTests correlated well with the Emit d.a.u. and GC-MS data when operating above the cutoff concentrations specified for these methods. RapiTest MOP was found to have crossreactivity with codeine and ethylmorphine, and RapiTest MET crossreacted with amphetamine.

摘要

将使用RapiTest THC（一步法δ9 - 四氢大麻酚检测）、RapiTest MOP（一步法吗啡检测）、RapiTest MET（一步法甲基苯丙胺检测）和RapiTest COC（一步法可卡因检测）获得的结果与使用Emit d.a.u.以及气相色谱 - 质谱联用（GC - MS）方法获得的结果进行比较。总共对从药理学和毒理学实验室提交进行常规分析的标本中采集的81份尿液样本进行了分析。样本先用Emit进行筛查，再通过RapiTests重新分析，并使用GC - MS方法进行定量分析。对阳性和阴性尿液样本均进行了检测。当在这些方法规定的临界浓度以上操作时，用RapiTests获得的结果与Emit d.a.u.和GC - MS数据具有良好的相关性。发现RapiTest MOP与可待因和乙基吗啡有交叉反应，RapiTest MET与苯丙胺有交叉反应。