Mizutani T, Onoda K, Katayama Y, Shikano K, Takeuchi Y, Yada I, Yuasa H, Kusagawa M
Department of Thoracic and Cardiovascular Surgery, Mie University School of Medicine, Japan.
Cardiovasc Surg. 1993 Oct;1(5):563-8.
It is now possible experimentally to measure myocardial blood flow of the beating heart using a helium-neon (He-Ne) laser Doppler flowmeter. A myocardial probe was redesigned to reduce its size and weight, and a method devised of fixing the probe to the beating cardiac surface to allow its clinical application. This modified laser flowmeter was used on 36 patients with ischaemic heart disease to measure myocardial blood flow before and after revascularization. Flow was measured in the right and left ventricles while patients were in a haemodynamically stable state as determined by electrocardiography, heart rate, blood pressure and double product (heart rate x systolic blood pressure). No significant difference was found between the mean(s.e.m.) preoperative and postoperative flow volume at the anterior wall of the right ventricle (77(15) versus 81 (12)ml/min per 100 g), which did not undergo revascularization, but mean(s.e.m.) myocardial blood flow at the ischaemic left ventricle increased significantly (from 68(15) to 88(13) ml/min per 100 g; P < 0.01). There was also no significant difference between preoperative and postoperative values of haemodynamic parameters of coronary blood flow. In conclusion, a means to measure myocardial blood flow with He-Ne laser Doppler flowmetry has been devised which shows coronary artery bypass grafting to increase myocardial blood flow in the ischaemic myocardium.
现在可以通过实验使用氦氖（He-Ne）激光多普勒流量计测量跳动心脏的心肌血流量。重新设计了心肌探头以减小其尺寸和重量，并设计了一种将探头固定在跳动心脏表面的方法以使其能够临床应用。这种改良的激光流量计用于36例缺血性心脏病患者，在血管重建前后测量心肌血流量。在通过心电图、心率、血压和双乘积（心率×收缩压）确定患者血流动力学稳定的状态下，测量右心室和左心室的血流量。未进行血管重建的右心室前壁术前和术后平均（标准误）血流量之间未发现显著差异（分别为每100克77（15）和81（12）毫升/分钟），但缺血左心室的平均（标准误）心肌血流量显著增加（从每100克68（15）增加到88（13）毫升/分钟；P<0.01）。冠状动脉血流动力学参数的术前和术后值之间也没有显著差异。总之，已经设计出一种用He-Ne激光多普勒血流仪测量心肌血流量的方法，该方法显示冠状动脉搭桥术可增加缺血心肌的心肌血流量。
