一条与山羊对CAE病毒诱导性关节炎易感性相关的DNA指纹图谱带。

A DNA fingerprinting band associated with the susceptibility to CAE virus-induced arthritis in goats.

作者信息

Dolf G, Ruff G

机构信息

Institute of Animal Breeding, University of Berne, Switzerland.

出版信息

Br Vet J. 1994 Jul-Aug;150(4):349-53. doi: 10.1016/s0007-1935(05)80151-4.

DOI:10.1016/s0007-1935(05)80151-4

PMID:8076168

Abstract

Caprine arthritis-encephalitis (CAE) virus-induced arthritis can be found in all Swiss goat breeds and it has been shown that there is a genetic pre-disposition for this disease. The 10 Toggenburg, 32 Chamois coloured and 40 Saanen goats, specially selected for this study, were naturally infected with CAE virus. Within each breed there was an equal distribution between clinically healthy animals and animals suffering from arthritis. In the case of the Saanen goats, a DNA fingerprint band generated with the multi-locus probe pV47 was identified associated with susceptibility to CAE virus-induced arthritis. In the Chamois coloured goats, no association was found. Another candidate DNA fingerprint band was present in clinically healthy animals of the Toggenburg breed but their number was insufficient for analysis.

摘要

山羊关节炎-脑炎（CAE）病毒引起的关节炎在所有瑞士山羊品种中都能发现，并且已经表明这种疾病存在遗传易感性。为这项研究特意挑选的10只托根堡山羊、32只羚羊色山羊和40只萨能山羊自然感染了CAE病毒。在每个品种中，临床健康的动物和患有关节炎的动物分布均衡。就萨能山羊而言，已确定用多位点探针pV47产生的一条DNA指纹带与对CAE病毒引起的关节炎的易感性相关。在羚羊色山羊中，未发现相关性。另一条候选DNA指纹带出现在托根堡品种的临床健康动物中，但数量不足以进行分析。