子宫因素在自发性高血压大鼠高血压发展中的作用。

Role of uterine factors in the development of hypertension in SHR.

Di Iulio J, Lucente F, Bramich C, Morgan T, Di Nicolantonio R

Department of Physiology, University of Melbourne, Parkville, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1994 Mar;21(3):239-42. doi: 10.1111/j.1440-1681.1994.tb02505.x.

Abstract

To examine whether the uterine environment plays a role in the development of hypertension in the spontaneously hypertensive rats (SHR), we have compared fetal weight, placental weight, and amniotic fluid composition of SHR and Wistar-Kyoto (WKY) rats after 20 days of gestation. 2. Pregnant SHR and WKY were anaesthetized at 20 days of gestation and the uterus and embryonic sacs removed. Fetal and placental weights were recorded and amniotic fluid collected for measurement of volume, osmolality and electrolyte composition. 3. No significant difference was found in litter size and placental weight between SHR and WKY. Total embryonic sac weight and fetal weight of SHR were significantly lower than WKY. Amniotic fluid volume, sodium concentration and osmolality of SHR were significantly higher than WKY, while amniotic fluid potassium concentration of SHR was significantly lower than WKY. 4. Thus, the SHR foetus was significantly underweight compared to the WKY and was bathed in amniotic fluid with a significantly higher osmolality and sodium concentration. As the mature foetus is known to drink amniotic fluid, it is hypothesized that the elevated Na/K ratio in SHR amniotic fluid may instigate or accelerate the hypertensive process.

摘要

为了研究子宫环境是否在自发性高血压大鼠（SHR）的高血压发展中起作用，我们比较了妊娠20天后SHR和Wistar-Kyoto（WKY）大鼠的胎儿体重、胎盘重量和羊水成分。2. 妊娠20天时，将怀孕的SHR和WKY麻醉，取出子宫和胚胎囊。记录胎儿和胎盘重量，并收集羊水以测量体积、渗透压和电解质成分。3. SHR和WKY之间的窝仔数和胎盘重量没有显著差异。SHR的总胚胎囊重量和胎儿体重显著低于WKY。SHR的羊水体积、钠浓度和渗透压显著高于WKY，而SHR的羊水钾浓度显著低于WKY。4. 因此，与WKY相比，SHR胎儿明显体重不足，并且浸泡在渗透压和钠浓度明显更高的羊水中。由于已知成熟胎儿会吞咽羊水，因此推测SHR羊水中升高的钠/钾比值可能会引发或加速高血压进程。