Van de Voorde W, Meertens B, Baert L, Lauweryns J
Department of Pathology I, University Hospital, St Rafaël, Leuven, Belgium.
Eur J Surg Oncol. 1994 Aug;20(4):478-83.
We reviewed the few published cases of male urethral squamous cell carcinoma after urethroplasty. A new case report is added. Considering the known facts we conclude that urethral cancer following urethroplasty, performed to cure urethral stricture, is a rare complication. One must be aware of possible evolution to malignancy when this surgical procedure is not fully successful, i.e. in the case of recurring urinary obstruction or disturbed wound healing. Alarming symptoms are fistulization, abscess formation, ulceration and induration. Histopathological examination is needed, firstly before urethroplasty to exclude already existing malignant changes of the urethral mucosa and secondly whenever suspicion is raised after surgery. It is of utmost importance to diagnose a urethral carcinoma as early as possible because the cure rate in advanced stage is minimal.
我们回顾了已发表的少数几例尿道成形术后男性尿道鳞状细胞癌的病例，并补充了一例新的病例报告。基于已知事实，我们得出结论：为治疗尿道狭窄而进行的尿道成形术后发生尿道癌是一种罕见的并发症。当该手术不完全成功时，即出现复发性尿路梗阻或伤口愈合不良的情况时，必须意识到可能会恶变为恶性肿瘤。警示症状包括形成瘘管、脓肿、溃疡和硬结。首先在尿道成形术前需要进行组织病理学检查，以排除尿道黏膜已存在的恶性病变，其次在术后出现任何可疑情况时也需要进行检查。尽早诊断尿道癌至关重要，因为晚期的治愈率极低。
