Colapinto V, Evans D H
J Urol. 1977 Oct;118(4):581-4. doi: 10.1016/s0022-5347(17)58111-2.
Most investigators agree that a urethral stricture is a predisposing cause of primary carcinoma of the urethra. The etiology of the carcinoma is probably chronic irritation. The role of squamous metaplasia in the etiology is discussed briefly. A case of primary squamous cell carcinoma of the urethra occurring 4 years after a first stage urethroplasty is reported and 2 cases from the literature are described. The suggested origins of urethral malignancy after urethroplasty are 1) unrecognized malignancy at operation, 2) premalignant mucosal changes that progress postoperatively, 3) recurrence of stricture with continued irritation leading to malignant metaplasia and 4) malignant change in the urethroplasty skin flaps. Although rare, primary male urethral carcinoma is a deadly disease. The hope for early diagnosis is a high index of suspicion during urethroplasty and in subsequent followup studies. The patient presented herein also exhibited pseudohyperparathyroidism as a result of the malignancy.
大多数研究者都认为尿道狭窄是原发性尿道癌的一个诱发因素。该癌症的病因可能是慢性刺激。本文简要讨论了鳞状化生在病因学中的作用。报告了1例在一期尿道成形术后4年发生的原发性尿道鳞状细胞癌病例，并描述了文献中的2例病例。尿道成形术后尿道恶性肿瘤的可能起源有：1）手术时未识别出的恶性肿瘤；2）术后进展的癌前黏膜改变；3）狭窄复发并持续受到刺激导致恶性化生；4）尿道成形术皮瓣发生恶性改变。原发性男性尿道癌虽然罕见，但却是一种致命疾病。早期诊断的希望在于在尿道成形术期间及后续随访研究中保持高度怀疑指数。本文所报道的患者还因恶性肿瘤而出现了假性甲状旁腺功能亢进。
