C3介导的细胞黏附。C3受体聚集体的形成是细胞附着的前提条件。
C3-mediated cytoadherence. Formation of C3 receptor aggregates as prerequisite for cell attachment.
作者信息
Dierich M P, Reisfeld R A
出版信息
J Exp Med. 1975 Jul 1;142(1):242-7. doi: 10.1084/jem.142.1.242.
Abstract
Inhibition of free movement of C3 receptors by either applying low temperature (3 degrees C) or fixing the cell surfce of lymphocytes with glutaraldehyde (2 times 10(-5) to 2 times 10(-1)%) results in loss of firm attachment of EAC142 3b cells to the lympocytes as demonstrated here by loss of rosette formation of Raji lymphoid cells. Under the same conditions soluble C3 can still bind but is unable to induce aggregation of C3 receptors into small patches. It is suggested that the local increase of C3 receptor density by aggregation is a prerequisite for C3-dependent cytoadherence. Microaggregation of corresponding receptor sites may be essential also in other recognition systems.
摘要
通过施加低温（3℃）或用戊二醛（2×10⁻⁵至2×10⁻¹%）固定淋巴细胞的细胞表面来抑制C3受体的自由移动，会导致EAC142 3b细胞与淋巴细胞的牢固附着丧失，如本文通过Raji淋巴细胞玫瑰花结形成的丧失所证明的那样。在相同条件下，可溶性C3仍能结合，但无法诱导C3受体聚集形成小斑块。有人提出，通过聚集使C3受体密度局部增加是C3依赖性细胞黏附的先决条件。相应受体位点的微聚集在其他识别系统中可能也至关重要。
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